Synthesis and in vitro study of modified chitosan polycaprolactamnanocomplex as delivery system. Rezvani M, Mohammadnejad J, Narmani A, Bidaki K. Evaluation of the PEG fensity in the PEGylated chitosan nanoparticles as a drug carrier for curcumin and mitoxantrone. 2020 22:31.Ĭhen Y, Wu D, Zhong W, Kuang S, Luo Q, Song L, et al. Breast tumor targeting with PAMAM-PEG-5FU-99mTc as a new therapeutic nanocomplex: in in-vitro and in-vivo studies. Narmani A, Arani MAA, Mohammadnejad J, Vaziri AZ, Solymani S, Yavari K, et al. Synthesis and evaluation of polyethylene glycol- and folic acid-conjugated polyamidoamine G4 dendrimer as nanocarrier. Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems. Narmani A, Rezvani M, Farhood B, Darkhor P, Mohammadnejad J, Amini B, et al. One-pot synthesis of metal–organic frameworks with encapsulated target molecules and their applications for controlled drug delivery. Zheng H, Zhang Y, Liu L, Wan W, Guo P, Nystrom AM, et al.
![ali 3328 editor ali 3328 editor](https://hess.copernicus.org/articles/24/5759/2020/hess-24-5759-2020-f14-web.png)
Biomimetic mineralization of metal–organic frameworks around polysaccharides. Liang K, Wang R, Boutter M, Doherty CM, Mulet X, Richardson JJ. Optimized metal_organic- framework nanospheres for drug delivery: evaluation of small-molecule encapsulation. Zhuang J, Kuo CH, Chou LY, Liu DY, Weerapana E, Tsung CK. A multifunctional metal–organic framework based tumor targeting drug delivery system for cancer therapy. Wang XG, Dong ZY, Cheng H, Wan SS, Chen WH, Zou MZ, et al. Highly sensitive and accurate detection of Vibrio cholera O1 OmpW gene by fluorescence DNA biosensor based on gold and magnetic nanoparticles. Narmani A, Kamali M, Amini B, Kooshki H, Amini A, Hassani L. Chitosan-based colloidal polyelectrolyte complexes for drug delivery: a review. Wu D, Zhu L, Li Y, Zhang X, Xu S, Yang G, et al. Dendrimers as efficient nanocarriers for the protection and delivery of bioactive phytochemicals. Hypoxia-responsive nanoparticle based drug delivery systems in cancer therapy: an up-to-date review. Gadolinium nanoparticles as diagnostic and therapeutic agents: their delivery systems in magnetic resonance imaging and neutron capture therapy. Narmani A, Farhood B, Haghi-Aminjan H, Mortezazadeh T, Aliasgharzadeh A, Mohseni M, et al. Overcoming blood-brain barrier transport: advances in nanoparticle-based drug delivery strategies.
![ali 3328 editor ali 3328 editor](https://www.eurekaselect.com/images/graphical-abstract/eeeng/13/8/011.jpg)
Targeting delivery of oxaliplatin with smart PEG-modified PAMAM G4 to colorectal cell line: in vitro studies. Narmani A, Kamali M, Panahi Y, Amini B, Salimi A.
![ali 3328 editor ali 3328 editor](https://www.researchgate.net/publication/354979304/figure/tbl3/AS:1075414894145536@1633410299252/Heating-characteristics-at-H0170Oe-and-f-3328-kHz_Q320.jpg)
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Results remarkably indicate the inhibited growth of colon cancer cells and induced cell apoptosis which suggests MCFL224 as a promising nanocomposite for colon cancer therapy.įerlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. In these investigations, decreased cell viability (14.22 ± 0.3% after 72 h treatment), increased apoptotic and autophagy-related genes expression level (BECLIN1: 34-folds, BAX: 36-folds, mTORC1: 10-folds, and Caspase-9: 9-folds more than control), higher cell cycle arrest in sub-G1 phase (19.53% of cells in sub-G1 phase), and more apoptosis analyses (late apoptosis: 67.7%) were evaluated in colon cancer cells treated with MCFL224 nano-complex. Then, in vitro assays were implemented on HCT116 (folic acid receptor-positive colon cancer cell line) and CRL1831 (normal colon cell line) to evaluate the therapeutic efficiency of the MCFL224 nano-complex. The entrapment efficiency of LNA-antisense miR-224 was calculated 72 ± 5% and a significant release profile of LNA-antisense miR-224 was observed at first 6 h (about 50%). The size range of NMOF-CS-FA-LNA-antisense miR-224 (MCFL224) nano-complex was obtained nearly at 200 nm. The prepared nano-complex was characterized by analytical devices such as FT-IR, UV-Vis spectrophotometry, DLS, TEM, and XRD. LNA-antisense miR-224 as a therapeutic sequence was able to considerably block highly expressed miR-224 and downregulated cancer cell growth. In this research, a novel zinc-based nanoscale metal-organic framework (Zn-NMOF) coated with folic acid (FA) functionalized chitosan (CS) has been constructed and applied as efficient delivery of LNA (locked nucleic acid)-antisense miR-224 to colon cancer cell lines. Targeted delivery of therapeutic agents is an advantageous approach by which cancer cells can be targeted without harming normal cells, and eliminates the negative effects of conventional therapies such as chemotherapy. Nowadays, nano-compartments are considered as an effective drug delivery system (DDS) for cancer therapy.